4(3H)-Quinazolinone, 2-[[4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-


Chemical Name: 4(3H)-Quinazolinone, 2-[[4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-
CAS Number: 900185-02-6
Product Number: AG00GU9E(AGN-PC-04TMY3)
Synonyms:
MDL No:
Molecular Formula: C28H23N7O2
Molecular Weight: 489.5279

Identification/Properties


Computed Properties
Molecular Weight:
489.539g/mol
XLogP3:
4.2
Hydrogen Bond Donor Count:
2
Hydrogen Bond Acceptor Count:
7
Rotatable Bond Count:
4
Exact Mass:
489.191g/mol
Monoisotopic Mass:
489.191g/mol
Topological Polar Surface Area:
123A^2
Heavy Atom Count:
37
Formal Charge:
0
Complexity:
870
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

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Chemical Structure



PIK-294 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K), a crucial enzyme involved in various cellular processes. In chemical synthesis, PIK-294 plays a key role as a valuable tool for investigating the PI3K signaling pathway and its impact on cell growth, proliferation, and survival.Its high specificity towards PI3K allows researchers to manipulate and study the intricate signaling cascades involved in various biological processes. This targeted inhibition can lead to a better understanding of disease mechanisms and the development of potential therapeutic strategies.PIK-294 is particularly valuable in studying cancer biology, as dysregulation of the PI3K pathway is a common occurrence in many cancer types. By using PIK-294 in chemical synthesis, researchers can explore the potential of targeting this pathway for cancer treatment.Furthermore, PIK-294's precise targeting of PI3K minimizes off-target effects, making it a reliable tool for modulating cellular responses without unwanted side effects. Its versatility and specificity make it a valuable asset in the field of chemical synthesis and drug discovery.