1. Home
  2. PF-03814735

Contact Angene

Tel: +852 8191 6999

Email: [email protected]

Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

PF-03814735

CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1c1c2ccc(c1)Nc1ncc(c(n1)NC1CCC1)C(F)(F)F Request for Quotation
Chemical Name: PF-03814735
CAS Number: 942487-16-3
Product Number: AG00GU5D(AGN-PC-050WJF)
Synonyms:
MDL No:
Molecular Formula: C23H25F3N6O2
Molecular Weight: 474.4788

Identification/Properties

Computed Properties
Molecular Weight:
474.488g/mol
XLogP3:
3
Hydrogen Bond Donor Count:
3
Hydrogen Bond Acceptor Count:
9
Rotatable Bond Count:
6
Exact Mass:
474.199g/mol
Monoisotopic Mass:
474.199g/mol
Topological Polar Surface Area:
99.2A^2
Heavy Atom Count:
34
Formal Charge:
0
Complexity:
778
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
2
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information

NMR Spectrum

Other Analytical Data

Request for Quotation

Customer Feedback

Chemical Structure


Pf-03814735, also known as Axinastatin 2 or Pyrimidin-4-yl 4-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenyl ether, is a potent and selective inhibitor of the enzyme glycogen synthase kinase-3 (GSK-3). In chemical synthesis, Pf-03814735 is utilized as a valuable tool for modulating various cellular processes due to its ability to target and inhibit GSK-3 activity.One key application of Pf-03814735 in chemical synthesis is its role in the development of novel drug candidates. By specifically targeting GSK-3, Pf-03814735 can influence signaling pathways involved in a wide range of biological functions, including cell proliferation, differentiation, and apoptosis. This makes it a promising compound for the design and synthesis of new therapeutic agents for various diseases, such as cancer, neurodegenerative disorders, and inflammatory conditions.Furthermore, Pf-03814735 can also be employed in studying the role of GSK-3 in cellular processes and disease pathways. Its selective inhibition of GSK-3 allows researchers to investigate the function of this enzyme in signaling cascades and explore its potential as a therapeutic target. By using Pf-03814735 in chemical synthesis, scientists can gain insight into the molecular mechanisms underlying complex biological systems and develop innovative approaches for drug discovery and development.Overall, Pf-03814735 serves as a valuable tool in chemical synthesis for exploring the functions of GSK-3 and its potential implications in disease mechanisms, paving the way for the development of novel therapeutic interventions with enhanced specificity and efficacy.