Quinazoline, 2-chloro-6,7-dimethoxy-


Chemical Name: Quinazoline, 2-chloro-6,7-dimethoxy-
CAS Number: 94644-47-0
Product Number: AG00338N(AGN-PC-0K9DF0)
Synonyms:
MDL No: MFCD06249130
Molecular Formula: C10H9ClN2O2
Molecular Weight: 224.6437

Identification/Properties


Properties
Storage:
Keep in dry area;2-8℃;
Computed Properties
Molecular Weight:
224.644g/mol
XLogP3:
2.4
Hydrogen Bond Donor Count:
0
Hydrogen Bond Acceptor Count:
4
Rotatable Bond Count:
2
Exact Mass:
224.035g/mol
Monoisotopic Mass:
224.035g/mol
Topological Polar Surface Area:
44.2A^2
Heavy Atom Count:
15
Formal Charge:
0
Complexity:
218
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information


GHS Pictogram:
Signal Word:
Warning
UN#:
N/A
Hazard Statements:
H302-H315-H319-H335
Precautionary Statements:
P261-P305+P351+P338
Class:
N/A
Packing Group:
N/A

NMR Spectrum


Other Analytical Data


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Chemical Structure



The application of 2-Chloro-6,7-dimethoxyquinazoline in chemical synthesis is particularly notable in the field of medicinal chemistry and pharmaceutical research. This compound serves as a key intermediate in the synthesis of various biologically active molecules and pharmaceuticals. Its unique structure and reactivity make it a valuable building block for the introduction of specific functional groups or modifications in organic molecules. 2-Chloro-6,7-dimethoxyquinazoline is commonly used as a versatile starting material for the preparation of quinazoline derivatives, which have demonstrated a wide range of pharmacological activities, including anti-cancer, anti-inflammatory, and antimicrobial properties. The presence of the chloro and methoxy substituents in the quinazoline core provides opportunities for further derivatization, allowing researchers to tailor the properties of the final product for specific applications.In chemical synthesis, this compound can be employed in various reactions such as nucleophilic substitution, condensation, and cyclization processes to access diverse structural motifs. Its reactivity towards different functional groups enables chemists to design efficient synthetic routes for the production of new drug candidates or bioactive compounds. Additionally, the ability to fine-tune the substitution pattern on the quinazoline scaffold offers opportunities for structure-activity relationship studies, crucial in drug discovery and optimization.Overall, the utilization of 2-Chloro-6,7-dimethoxyquinazoline in chemical synthesis enables scientists to access a wide array of novel compounds with potential pharmaceutical applications, making it an invaluable tool in the development of new therapeutic agents.