4-Isocyanato-1,1′-biphenyl, also known as ICBP, is a versatile chemical compound frequently employed in chemical synthesis processes. This compound serves as a valuable building block in the creation of various organic molecules due to its unique reactivity and structural characteristics.In chemical synthesis, 4-Isocyanato-1,1′-biphenyl plays a crucial role as a diisocyanate reagent. Its isocyanate functional group (-N=C=O) is highly reactive towards a variety of nucleophiles, enabling the formation of urea, carbamate, and urethane linkages. This reactivity makes it a key component in the synthesis of polyurethane materials, which are widely used in industries such as coatings, adhesives, and foams.Furthermore, the biphenyl backbone of 4-Isocyanato-1,1′-biphenyl imparts rigidity and steric effects that influence the regioselectivity and stereochemistry of the products formed in its reactions. This structural feature allows for the selective functionalization of specific positions on the biphenyl ring, enabling the tailored synthesis of complex organic molecules with controlled properties and functionalities.Overall, the application of 4-Isocyanato-1,1′-biphenyl in chemical synthesis offers chemists a powerful tool for constructing diverse molecular structures and materials with precise control over reactivity and selectivity.