Chemical Name: | Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]- |
CAS Number: | 69504-07-0 |
Product Number: | AG00FGDF(AGN-PC-0OGRR1) |
Synonyms: | |
MDL No: | |
Molecular Formula: | C23H31N5O5Si |
Molecular Weight: | 485.6082 |
2'-TBDMS-Bz-rA, or 2'-O-tert-butyldimethylsilylbenzoyl adenosine, is a valuable reagent widely used in chemical synthesis for its unique properties and applications. This versatile compound plays a crucial role in nucleoside chemistry, specifically in the modification and protection of RNA molecules. 2'-TBDMS-Bz-rA is commonly employed as a building block in the synthesis of modified RNA strands, where its tert-butyldimethylsilyl (TBDMS) and benzoyl (Bz) groups serve as protective functionalities for the adenosine nucleoside.In chemical synthesis, 2'-TBDMS-Bz-rA acts as a masked adenosine unit that can be selectively deprotected under specific conditions to reveal the reactive adenosine moiety. This controlled deprotection allows for precise manipulation of the RNA backbone, enabling researchers to introduce targeted modifications or functional groups at desired sites within the RNA sequence. Furthermore, the tert-butyldimethylsilyl group provides enhanced stability and protection to the adenosine nucleoside during various synthetic steps, ensuring high yields and purity of the final RNA product.Overall, the strategic use of 2'-TBDMS-Bz-rA in chemical synthesis offers a powerful and versatile approach for the synthesis of modified RNA molecules with enhanced structural and functional diversity. Its unique combination of protective groups makes it an indispensable tool for researchers working in the field of nucleic acid chemistry and RNA engineering.