Chemical Name: | L-Histidine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-[(4-methylphenyl)sulfonyl]- |
CAS Number: | 112380-10-6 |
Product Number: | AG007TI0(AGN-PC-0P3DV1) |
Synonyms: | |
MDL No: | MFCD00144353 |
Molecular Formula: | C28H25N3O6S |
Molecular Weight: | 531.5796 |
Fmoc-His(Tos)-OH, also known as N-(9-fluorenylmethoxycarbonyl)-L-histidine tosylate, is a commonly used amino acid derivative in chemical synthesis. This compound is particularly useful in peptide synthesis due to its ability to protect the histidine residue during the assembly of peptide chains.In peptide synthesis, Fmoc-His(Tos)-OH serves as a building block for incorporating histidine into the peptide sequence. The Fmoc (9-fluorenylmethyloxycarbonyl) group acts as a protecting group, which can be selectively removed under mild conditions to expose the reactive amine group of histidine for further coupling reactions. The tosyl (Tos) group provides additional protection to the imidazole side chain of histidine, enabling specific reactions to take place without undesired side reactions.Overall, the application of Fmoc-His(Tos)-OH in chemical synthesis allows for the controlled and efficient synthesis of histidine-containing peptides, which are important in various fields such as pharmaceuticals, biochemistry, and materials science.