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Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

ABT-888

NC(=O)c1cccc2c1nc([nH]2)[C@@]1(C)CCCN1.Cl.Cl Request for Quotation
Chemical Name: ABT-888
CAS Number: 912445-05-7
Product Number: AG006PFC(AGN-PC-0VRX87)
Synonyms:
MDL No: MFCD16661206
Molecular Formula: C13H18Cl2N4O
Molecular Weight: 317.2142

Identification/Properties

Computed Properties
Molecular Weight:
317.214g/mol
Hydrogen Bond Donor Count:
5
Hydrogen Bond Acceptor Count:
3
Rotatable Bond Count:
2
Exact Mass:
316.086g/mol
Monoisotopic Mass:
316.086g/mol
Topological Polar Surface Area:
83.8A^2
Heavy Atom Count:
20
Formal Charge:
0
Complexity:
348
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
1
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
3
Compound Is Canonicalized:
Yes

Safety Information

NMR Spectrum

Other Analytical Data

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Chemical Structure


ABT-888, also known as veliparib, is a potent inhibitor of the enzyme poly (ADP-ribose) polymerase (PARP). In chemical synthesis, ABT-888 plays a crucial role in various applications, particularly in the field of medicinal chemistry and drug development.As a PARP inhibitor, ABT-888 has been extensively utilized in the synthesis of novel pharmaceutical compounds targeting cancer cells. PARP enzymes play a vital role in DNA damage repair mechanisms, and by inhibiting these enzymes, ABT-888 can enhance the effectiveness of chemotherapy treatments in cancer patients. This synergistic effect makes ABT-888 a valuable tool in the development of combination therapies for cancer.Furthermore, ABT-888 has shown promising results in enhancing the efficacy of DNA-damaging agents by preventing the repair of damaged DNA in cancer cells. This ability to potentiate the effects of existing chemotherapeutic agents makes ABT-888 a valuable asset in the field of chemical synthesis for designing more effective and targeted cancer treatments.In addition to cancer therapy, ABT-888 has also been explored in other areas of chemical synthesis, such as in the development of novel small-molecule inhibitors and the elucidation of PARP enzyme functions. Its versatility and potency in inhibiting PARP make ABT-888 a versatile tool in the hands of synthetic chemists and medicinal chemists alike.