2-(2-Fluoro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a versatile compound widely used in chemical synthesis. This boronic ester derivative serves as a valuable building block in organic chemistry due to its unique properties.In chemical synthesis, 2-(2-Fluoro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is commonly employed in Suzuki-Miyaura cross-coupling reactions. This reaction involves the coupling of an aryl or vinyl boronic acid with an organic halide or triflate, catalyzed by a palladium complex. By incorporating this dioxaborolane compound as a boron-containing starting material, chemists can efficiently construct complex organic molecules with high regio- and stereoselectivity.Furthermore, the presence of the fluoro and methoxy substituents on the phenyl ring confers specific reactivity and selectivity in cross-coupling reactions. The fluorine atom can influence the electronic properties of the aromatic ring, while the methoxy group can serve as a directing group for the regioselective functionalization of the phenyl moiety.Overall, the application of 2-(2-Fluoro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in chemical synthesis enables synthetic chemists to access diverse molecular frameworks efficiently and with high precision.
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